Hydroalcoholic extract of Zataria multiflora mitigates cisplatin-induced oxidative stress, apoptosis and hepatotoxicity in mice
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چکیده
منابع مشابه
Zataria multiflora ameliorates cisplatin-induced testicular damage via suppression of oxidative stress and apoptosis in a mice model
Objective(s): Cisplatin (CP), as an anti-neoplastic drug, causes testicular damage. Zataria multiflora Boiss (ZM), a medicinal plant, has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effects of ZM against CP-induced testicular toxicity. Materials and Methods: In this experimental study, thirty-two adult male mice were randomly divided into four group...
متن کاملThe effect of Zataria multiflora Boiss hydroalcoholic extract and fractions in pentylenetetrazole-induced kindling in mice
OBJECTIVE At present, there are many antiepileptic drugs with a wide range of side effects on the human body. It was assumed that Zataria multiflora Boiss (Z. multiflora) with sedative, anti-spasmodic and anti-inflammatory activity may be effective in the treatment of epilepsy. The aim of the present study was to elucidate the effect of Z. multiflora hydroalcoholic extract and its fraction extr...
متن کاملProtective effect of Zataria multiflora on hepatotoxicity induced by cisplatin in mice
Background and objectives: Cisplatin (CP), the chemotherapy drug, is used for the treatment of many types of cancer but causes hepatotoxicity. Zataria multiflora Boiss. (ZM), is a widely used herbal medicine with potent antioxidant properties. This study aimed to assess the protective effect of Zataria multiflora against cisplatin-induced hepatotoxicity. <strong...
متن کاملThe effect of Zataria multiflora Boiss hydroalcoholic extract and fractions in pentylenetetrazole-induced kindling in mice
Objective: At present, there are many antiepileptic drugs with a wide range of side effects on the human body. It was assumed that Zataria multiflora Boiss (Z. multiflora) with sedative, anti-spasmodic and anti-inflammatory activity may be effective in the treatment of epilepsy. The aim of the present study was to elucidate the effect of Z. multiflora hydroalcoholic extract and its fraction ext...
متن کاملHepatoprotective effect of Zataria Multiflora Boisson cisplatin-induced oxidative stress in male rat
Background: This research aimed to evaluate the protective effects of methanolic extract of Zataria Multiflora Boiss (Z. Multiflora) against hepatic damage induced by cisplatin in male Wistar rats. Methods: Hepatotoxicity was induced in Wistar male rats by a single intraperitoneal administration of cisplatin, 7 g/ kg body weight. A methanolic extract of Z. Multiflora was administered orally at ...
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ژورنال
عنوان ژورنال: Journal of Research in Pharmacy
سال: 2018
ISSN: 2630-6344
DOI: 10.12991/jrp.2018.78